The PrEP initiative has 3 core components focused on providers, users, and measuring impact.
Improved user knowledge and access
- Broad-based education campaign to reach into heavily impacted communities
- User hotline for information, resources
- Website as “one-stop shop” of local and national resources and information
- Affordability program including navigators to assist potential users with insurance and provider choice, access to co-pay/deductible/payment assistance
- Speakers bureau of PrEP users
- Programs to support PrEP adherence
Increased provider capacity
- Support for public-access PrEP clinics
- Training, resources for providers in diverse fields (primary care, Ob/Gyn, pediatrics, psychiatry)
- Warm line for providers
- Online tools
- Cultural humility training for providers
Tracking PrEP uptake and impact
- Measure PrEP use citywide (including demographics and behavior of PrEP users, duration of use, type of PrEP)
- Track potential negative consequences (e.g., breakthrough infections, resistance, social harms, STIs, difficulty accessing PrEP)
- Track potential benefit (e.g., impact on HIV incidence, access to comprehensive health services for PrEP users)
- Track sexual and injection behaviors over time
- Track PrEP- and HIV-associated stigma
- Measure cost to providers, payers, users
PrEP Committee Resources
Resources for individuals interested in PrEP and doxy-PEP
- PrEP Basics Fact Sheet/Lo Esencial de PrEP – by San Francisco Department of Public Health
- Injectable PrEP Basics Fact Sheet/Lo Esencial de la PrEP inyectable — by San Francisco Department of Public Health
- PrEP Options (comparison chart pill & injectable option) – SFAF (English and Spanish)
- List of Clinics in SF Offering Long-Acting Injectable (LAI) for HIV PrEP & Treatment for prevention and treatment, clients they serve, and healthcare coverage they accept
doxy-PEP
- About Doxy-PEP Fact Sheet — San Francisco City Clinic
- Acerca de Doxy-PEP — San Francisco City Clinic
Resources for providers & frontline workers
- Page of resources
- Ask about PrEP: How providers can prescribe PrEP to prevent HIV and reduce health disparities – San Francisco Department of Public Health
- Prescribing oral PrEP Pocket Card – by San Francisco Department of Public Health
- PrEP Navigation Manual: Helping People Access Pre-Exposure Prophylaxis – PleasePrEPMe.org & getSFcba
Injectable PrEP
- Ward 86 Long Acting Pre-Exposure Prophylaxis (PrEP) Guidelines (CAB LA and LEN LA), November 2025
- SFDPH Whole Person Integrated Care (WPIC): Long-Acting Injectable ART & PrEP Protocols, May 2025
- Long-Acting Injectable (LAI) ART & PrEP: The frontline worker’s role in team-based care (English, Spanish) – SF HIV FOG
- Injectable HIV Medications and PrEP – Resources compiled by East Bay Getting to Zero
- Yeztugo Insurance Flowsheet
- Apretude Insurance Flowsheet
PrEP News & Updates
Latest from PrEP Committee
Truvada® is going generic on September 30, 2020: Update for San Francisco PrEP Users (updated 10/14)
Where can I learn more?If you or your provider have any questions, please contact San Francisco City Clinic at sfccpatientservices.dph@sfdph.org. For more information on generic medications, the FDA maintains information at its Generic Drug Facts page.
Updated resource from SFAF: Which PrEP medication is best for me? Here’s how Truvada, Descovy, Apretude, and Yeztugo compare.
If you have questions about this chart or accessing PrEP, please email prep@sfaf.org From SFAF Resource Library here.
*UPDATED* ‘Dear Colleague’ Letter – SFDPH offering guidance on several topics related to HIV prevention
Click below to download the full *updated* Dear Colleague Letter. Dear Colleague, We’re writing to share with you recommendations on how to incorporate new developments in HIV prevention and care into your practice. The San Francisco Department of Public Health recommends that you: Screen all sexually active MSM, trans women, and trans men who have…
Mission Wellness to become first pharmacy in California to offer PrEP directly to consumers
By Nikole Trainor, MPH, MCHES, Maria Lopez, Pharm.D., AAHIVP & Stephanie Cohen, MD, MPH Mission Wellness Pharmacy in San Francisco became the first pharmacy in California to provide PrEP directly to consumers, without the need for a doctor’s prescription. In collaboration with the San Francisco Department of Public Health (SFDPH), and with support from the Getting to Zero consortium, Mission…